Hemolysins in spontaneous mouse breast tumors as compared to those in normal mouse tissue.

This paper is concerned with the nature of the hemolytic material which occurs in certain tumors, and particularly with the question whether it dif fers from the hemolytic material found in many normal tissues. The latter, at least in one of its forms, has been shown to have the characteristics of soaps and of lysolecithin-like substances more or less loosely combined with inhibitory material in lysin-inhibitor complexes (7, 9, 10). The soaps and lysolecithin-like substances can be extracted from these complexes with alcohol and are ex tremely lytic. The complexes themselves can be extracted with saline. Their hemolytic activity is much less than that of the alcohol-extractable substances. Their activity increases if the tissue is incubated at 37° C., probably because loosely com